Computational analysis of eugenol inhibitory activity in breast cancer cells has revealed that a compound in red wine, a powerful antioxidant, acts as an inhibitor of estrogen-like effects. Other antioxidants have been linked to this activity such as resveratrol and quercetin but in vitro results were inconsistent. In contrast, eugenol inhibits the estrogen action by a more direct effect on the DNA binding protein known as estrogen receptor-alpha.

The discovery of eugenol inhibitory activity is important because the role of estrogen is critical in maintaining a healthy body weight, bone structure and tissue maintenance. Estrogen is secreted by the ovary and works by binding to certain receptors in the cell nucleus. Estrogen is thought to be responsible for many of the well-known signs of aging, including vaginal dryness, loss of libido and insomnia. As we age, the estrogen levels in our body decline and with it, a wide range of symptoms associated with aging such as joint pain, constipation, and weight gain.

The researchers have also uncovered another way the eugenol inhibitory activity affects the health of the cells. Esterols are also involved in the regulation of gene transcription and DNA damage repair. Estrogens stimulate the transcription of genes that control cell metabolism and thus contribute to the development of fat cells and fat deposits.

Esters inhibit the formation of fat cells and cause the decrease in fat and fatty tissues. This reduction in fatty tissues results in reduced metabolic processes and a reduction in energy use. This reduction in metabolic processes reduces the ability of the cells to respond to insulin and glucose and results in the development of insulin resistance.

The study is published online in Science Express and has been accepted for publication in Nature Medicine. The research was performed at the Laboratory of Molecular Biology and Immunology, Hebrew University, Israel. Additional research is needed in order to determine whether the eugenol inhibitory activity has other important biological functions.

The researchers plan to continue their study of the role of eugenol inhibitory activity in the regulation of genes and metabolism, and also how to activate this action in combination with other important proteins. The ability to regulate gene transcription by the enzyme cytochrome could be used in cancer treatment, and the ability to interfere with the action of the estrogen receptor-alpha may play a vital role in treatment of diseases of the prostate and other organs.

However, the researchers are planning further research to determine the interaction of eugenol and the estrogen receptor-alpha. The findings should also reveal whether the cytochrome enzyme participates in the process of DNA binding, and whether cytochrome participates in the regulation of transcriptional regulation in other cells or in other disease processes. Because estrogen is involved in many cancers, the researchers plan to follow the effects of eugenol on cells from cancer that are highly responsive to this hormone, such as breast cancer.

The discovery is important because it helps researchers understand how cellular aging occurs. It may also provide important clues to stop or slow down the process of aging in the elderly and perhaps help to delay the process of cancer progression in the human body.

The research has a number of potential applications for humans and for genetic variation. For example, the ability to increase or decrease the production of the enzyme is being studied in humans and mice that have increased genetic variation in the genes involved in cell metabolism. In other words, this is the ability to control the production of the enzyme without affecting the other genes.

When the researchers are able to control cellular metabolism in this way, it may be possible to use genetic variation to reduce the aging process in humans and slow down the rate at which cellular aging increases in the human body. Thus, genetic variation may have an important role in preventing the disease and aging processes associated with genetic variation.

Variations of the cytochrome enzymes involved in cellular metabolism have a profound effect on cellular aging. This research, therefore, has the potential to impact a variety of medical conditions including human longevity. Computational analysis of the activity of cytochrome may be useful in predicting the impact of human aging on cellular metabolism and other health and medical conditions.